PHOSPHATIDYLSERINE ANTIBODIES, BLOOD
Enzyme-linked Immunosorben Assay (ELISA)
Includes IgA, IgG, and IgM.
	Test Performed At:
		Mayo Medical Laboratories #90014
	Specimen Required:
		Collect 5.0 mL (minimum 1.0 mL) of whole blood in a plain, red-top or serum gel tube(s).
	Laboratory Notes:
		Spin, separate and send 3.0 mL (minimum 0.3 mL) of serum refrigerated.
		NOTE:		Will also accept Sodium Citrate Plasma (light-blue top tube)
	Reference Values:
		Phosphatidylserine IgG Autoantibodies
			<10 Units/mL		Negative
			10-20 Units/mL		Equivocal – Found in small percentage of healthy population; may be reactive
			>20 Units/mL		Positive – Risk factor for thrombosis and pregnancy loss
		Clinical significance: The Antiphospholipid Antibody Syndrome (APS) is a clinical pathologic correlation that includes a clinical event (e.g. thrombosis, pregnancy loss, thrombocytopenia) and persistent positive Antiphospholipid Antibodies (IgM or IgG ACA >40 MPL/GPL, IgM or IgG anti-B2GP1 antibodies, or a Lupus Anticoagulant). The IgA isotype has been implicated in smaller studies, but have not yet been incorporated into the APS criteria. International consensus guidelines suggests waiting at least 12 weeks before retesting to confirm antibody persistence. Reference J Thromb Haemost 2006: 4;295
		Phosphatidylserine IgM Autoantibodies
			<25.0 Units/mL		Negative
			25-35 Units/mL		Equivocal – Found in small percentage of healthy population; may be reactive
			>35 units/mL		Positive – Risk factor for thrombosis and pregnancy loss
		Phosphatidylserine IgA Autoantibodies
			<20.0 Units/mL		Negative
			20-30 Units/mL		Equivocal – Found in small percentage of healthy population; may be reactive
			>30 Units/mL		Positive – Risk factor for thrombosis
	Day(s) Test Set Up:
		Tuesday, Thursday
	Cut-Off Time:
	Turn Around Time:
		5-10 days
	CPT Code:
		86148 x 3
	Care Manager Order Name:
		Anti-Phosphatidylerine Antibodies ONCE RTN
	KIDDOS Order Name:
		Anti Phosphatidylserine Antibodies
	Cerner Order Name:
		Phostidserin Ab

Last Updated 02/09