NEUROTRANSMITTER METABOLITES, SPINAL FLUID (5HIAA, HVA, 30MD)

 

Test Performed At:

 

 

Mayo Medical Laboratories to Medical Neurogenetics LLC    #91688

 

Specimen Required:

 

Call St. Louis Children’s Hospital at (314) 454-4161 for special collection containers kit and sample collection/ processing information. The total CSF volume required is 3.5 mL that will be aliquoted into 5 tubes provided. Attach patient identifier to each tube without covering the tube number. If there is no blood contamination, place the tubes into a biohazard bag and place on ice (or dry ice if available) at the bedside.

 

 

NOTE:

Please complete a Neurochemistry Test Request Form and forward it with the specimen.  You may also contact the lab at 314-454-4161 to obtain form.

 

Laboratory Notes:

 

Send one set of five tubes with a total CSF volume of 3.5 mL. EACH special collection container (1, 2 & 5) requires 0.5 mLs, while tubes 3 & 4 require 1.0 mL each.  If samples are not blood contaminated, freeze at -80°C immediately.

 

 

NOTES:

1.

If the sample is blood contaminated, the tubes should immediately be centrifuged prior to freezing) and the clear spinal fluid transferred to new similarly labeled tubes then frozen ASAP.

 

 

 

2.

Send a completed Neurochemistry Test Request Form with the specimen. 

 

 

 

3.

Sample should only be shipped Monday-Thursday.

 

 

 

4.

Ship specimen frozen on 3-4 lbs of dry ice by FedEx overnight express service.

 

 

 

5.

Specimen may also be used for Succinyladenosine, if requested

 

 

 

6.

Collection kits and instructions are stored in refrigerator 1 in core lab.

 

Reference Values:

 

 

Age

5HIAA

HVA

3-O-MD

 

 

(years)

(nmol/Liter)

(nmol/Liter)

(nmol/Liter)

 

 

 

 

 

 

 

 

0-0.2

208-1159

337-1299

<300

 

 

0.2-0.5

179-711

450-1132

<300

 

 

0.5-2.0

129-520

294-1115

<300

 

 

2.0-5.0

74-345

233-928

<150

 

 

5.0-10

66-338

218-852

<100

 

 

10-15

67-189

167-563

<100

 

 

Adults

67-140

145-324

<100

 

 

 

 

 

 

 

 

Interpretation performed by Keith Hyland, Ph.D.

 

 

 

 

 

 

 

 

NOTE:

If test results are inconsistent with the clinical presentation, please call our laboratory to discuss the case and/or submit a second sample for confirmatory testing.

 

Day(s) Test Set Up:

 

 

Monday – Friday

 

Cut-Off Time:

 

 

N/A

 

Turn Around Time:

 

 

2-3 weeks (14 days analytic time)

 

CPT Code:

 

 

82492

 

KIDDOS Order Name:

 

 

Neurotransmitter Metabolites CSF

 

Cerner Order Name:

 

 

CSF Neurotrans

 

Last Updated 01/10

Last Reviewed 01/10