CARDIOLIPIN ANTIBODIES, BLOOD
Enzyme-Linked Immunosorbent Assay (ELISA)
NOTE: This is a screening test for Cardiolipin antibody. If positive specific antibodies to IgA, IgG, and IgM will be performed.
	Test Performed At:
		St. Louis Children’s Hospital
	Specimen Required:
		Draw 2.0 mL of whole blood in a SST® (Serum Separator Tube) preferred; a plain, red-top tube(s) is acceptable; send to lab refrigerated.
	Laboratory Notes:
		Spin, separate and freeze.
	Reference Values:
		Negative
		NOTE:	Antibodies to cardiolipin are found in a number of diseases including systemic lupus erythematosus (SLE) and other connective tissue diseases as well as in patients with nonautoimmune diseases. In SLE and related disorders, anticardiolipin antibodies (ACA) are strongly associated with a number of clinical manifestations, including venous and arterial thrombosis, thrombocytopenia, and recurrent fetal loss. Approximately 30% of SLE patients will have ACA. Patients with non-SLE disorders account for about 50% of positive ACA results. ACA in normal populations range from 0.0-7.5%
	Day(s) Test Set Up:
		Screen: Wednesday
		Specific Cardiolipin Antibodies: Wednesday
	Cut-Off Time:
	Turn Around Time:
		2-8 days
	CPT Code:
		83516 - screen
		86147 - IgA, IgG, IgM (if appropriate)
	Care Manager Order Name:
		Cardiolipin Antibody Screen ONCE RTN
	Cerner Order Name:
		Cardio Ab Screen

Last updated 01/07