CARDIOLIPIN ANTIBODIES, IgA, IgG, AND IgM, BLOOD
Enzyme-Linked Immunosorbent Assay (ELISA)
NOTE:			If Cardiolipin Antibodies Screen is positive, the Cardiolipin Antibodies, IgA, IgG and IgM will be performed.
	Test Performed At:
		St. Louis Children’s Hospital
	Specimen Required:
		Draw 2.0 mL of whole blood in a SST® (Serum Separator Tube) preferred; a plain, red-top tube(s) is acceptable; send to lab.
	Laboratory Notes:
		Spin and separate.
	Reference Values:
		Reported as:
			Negative
			Low positive
			Moderate positive
			High positive
		Additional interpretative information provided with report.
		NOTE:		Antibodies to cardiolipin are found in a number of diseases including systemic lupus erythematosus (SLE) and other connective tissue diseases as well as in patients with nonautoimmune diseases. In SLE and related disorders, anticardiolipin antibodies (ACA) are strongly associated with a number of clinical manifestations, including venous and arterial thrombosis, thrombocytopenia, and recurrent fetal loss. Approximately 30% of SLE patients will have ACA. Patients with non-SLE disorders account for about 50% of positive ACA results. ACA in normal populations range from 0.0-7.5%.
	Day(s) Test Set Up:
		Wednesday – reflex tests for positive Cardiolipin Antibodies Screen
	Cut-Off Time:
	Turn Around Time:
		2-8 days
	CPT Code:
		86147 x 3
	Care Manager Order Name:
		Cardiolipin Antibody, IgA ONCE RTN
		Cardiolipin Antibody, IgG ONCE RTN
		Cardiolipin Antibody, IgM ONCE RTN
	Cerner Order Name:
		Cardio IgA
		Cardio IgG
		Cardio IgM

Last Updated 01/07