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AMITRIPTYLINE AND NORTRIPTYLINE,
BLOOD (ELAVIL) |
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Methodology:
High-Pressure Liquid Chromatography (HPLC) |
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Test Performed At: |
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Mayo Medical Laboratories #8125 |
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Specimen Required: |
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Collect 5.0 mL
(minimum 2.5 mL) whole blood in a plain, red-top
tube(s) immediately before next scheduled dose (minimum 12 hours after last
dose). SERUM GEL TUBES ARE NOT ACCEPTABLE. |
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Laboratory Notes: |
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Spin, separate within 2 hours of
draw, and send 3.0 mL (minimum 1.1 mL) of serum refrigerated. |
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Reference Values: |
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Therapeutic Concentrations: (for
specimens drawn at trough) |
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Nortriptyline: 70-170 ng/mL |
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Amitriptyline + Nortriptyline:
80-200 ng/mL |
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Critical values (automatic
callback): |
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Nortriptyline:
³500 ng/mL |
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Amitriptyline + Nortriptyline: ³1,000 ng/mL |
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NOTE: |
Due to an analytical interference,
patients taking sertraline may have falsely low
results and patients taking clomipramine and amlodipine may have falsely elevated results. |
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Day(s) Test Set Up: |
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Monday – Saturday; Varies |
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Cut-Off Time: |
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Turn Around Time: |
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2-4 days |
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CPT Code: |
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80152 - amitriptyline |
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80182 - nortriptyline |
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KIDDOS Order Name: |
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Amitriptyline Profile |
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Cerner Order Name: |
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Amitriptyl Prof |
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Last Updated 10/09
Last Reviewed 10/09